Biomimetic bioreactors aim to recapitulate the main biophysical signals in a certain tissue or organ, while in the same time providing efficient mass transport and controlled cultivation conditions. This approach was primarily developed in the area of tissue engineering with the goal to promote functional tissue regeneration in vitro by imitating the native cell/tissue environment. Additionally, biomimetic bioreactors are valuable tools in characterization of novel biomaterials under physiologically relevant conditions such as cell-biomaterial interactions, biomaterial stability, performance and functionality. This session will cover recent approaches in development and utilization of biomimetic bioreactors providing various physical signals such as shear stresses, compression, torsion, hydrostatic pressure, and electrical signals, thus mimicking environments in different tissues and organs.